The effect of Biological Rhythm Disruption on Eating and Cognitive Behavior from the Viewpoint of Inflammation in the Brain

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K19421
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: Hyogo Medical University
• Principal Investigator: Kadoya Manabu 兵庫医科大学, 医学部, 講師 (90755109)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 睡眠 / 脳内炎症 / 認知機能 / 摂食

Outline of Final Research Achievements

We set up a short-time sleep model in which sleep can be taken during the same time period, and a combined sleep disorder model in which the sleep quality was reduced by randomly setting the sleep securing time zone every day. Focusing on the amount of food intake, the arcuate nucleus of the hypothalamus of the feeding center, and the hippocampal dentate gyrus of the cognitive memory center, microglia, inflammatory cytokines (TNFα, IL6), and neurogenesis were also evaluated. For cognitive function, the Y maze test and the Burns maze test were used.
As a result, cognitive behavior showed a significant decrease in the combined sleep disorder model, and the amount of food intake also decreased. However, no difference was observed by Iba1 staining, and no difference was observed in TNFα and IL6 in the hippocampus and cerebrum. In addition, there was no difference in Double cortin, which is an index of neurogenesis.

Free Research Field

衛生学

Academic Significance and Societal Importance of the Research Achievements

同じ時間帯に睡眠時間をとることに比べ、同じ睡眠時間であってもランダムに設定すると認知や摂食行動が低下することが観察された。このことは、スマートホンなどが普及している現代社会において、同じ時間帯での睡眠確保が認知機能などの保持に有用であり、逆に生活リズムが保てていないなど睡眠の質が低下している場合、将来的に認知機能や摂食量の低下から様々な合併症を来す可能性があることが示唆され、睡眠の質の確保の重要性を提示することができた。