Investigation of strategy to prevent mumps outbreaks among the youth

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K19445
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Nara Medical University (2023); Hyogo Medical University (2019-2022)
• Principal Investigator: Takeuchi Jiro 奈良県立医科大学, 医学部, 講師 (60791324)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: ワクチン接種 / 感染症予防 / 大学生 / ムンプス / ブレイクスルー感染 / 抗体価 / 母子健康手帳 / 横断研究

Outline of Final Research Achievements

We conducted a multicenter cross-sectional study to assess mumps breakthrough infection. Students from three universities participated in 2019. Informed consent was obtained from the students and their guardians. We collected data on past history and vaccination history using a questionnaire, photocopies of the Maternal and Child Health Handbook, and virus antibody titers. This study assessed 2004 students and included 593 (30%); of these, 250 (43%) had a mumps infection history. Furthermore, 264 (45%), 31 (5%), and 2 (0.3%) students received the first, second, and third doses of mumps vaccine. The mumps seropositivity prevalence was 43% (n = 127), 37% (n = 97), 27% (n = 8), and 100% (n = 2) (p for trend = 0.09), and the mumps infection prevalence rates were 70% (n = 203), 11% (n = 28), 4% (n = 1), and 0%, for the no-, first-, second-, and third-dose groups. Approximately 1 in 10 students receiving only one dose of mumps-containing vaccine had a breakthrough infection history.

Free Research Field

公衆衛生学

Academic Significance and Societal Importance of the Research Achievements

従来の報告では感染歴、ワクチン接種歴、ウイルス抗体価を全て組み合わせた報告は稀少だった。しかし本研究においては、いずれの情報も取得した上で、ムンプスワクチンにおけるワクチン接種回数ごとのブレイクスルー感染歴を明らかにした。ムンプスワクチン接種におけるブレイクスルー感染を明らかにした。今後のブレイクスルー感染を防ぐ方策を構築する際の資料となり得る。
加えて本調査では研究対象者全員におけるムンプスワクチン接種を実施した時点の自治体単位での接種助成の実態について補遺として掲載したため、今後の資料となる。