PCSK9 is Independently Associated with Insulin Resistance, Triglycerides, Lipoprotein(a) Levels, but not Low-density Lipoprotein Cholesterol Levels in a General Population

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K19447
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Kurume University
• Principal Investigator: Hamamura Hitoshi 久留米大学, 医学部, 助教 (00811085)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 脂質代謝

Outline of Final Research Achievements

We conducted a study on the relationship between PCSK-9 concentration and Lipoprotein(a) concentration in the general population in Ukushima, Sasebo City, Nagasaki Prefecture.Contrary to expectations, PCSK-9 levels in the general population were not associated with LDL-C, but were associated with Liporotein(a), triglycerides, and impaired glucose tolerance.In 2020, due to the spread of COVID-19 infectious disease, screening on remote islands could not be performed.However, by compiling past data, it was accepted by the "Journal of Atherosclerosis and Thrombosis" and made into a paper, and was presented at the 84th Annual Meeting of the Japanese Circulation Society in 2020.

Free Research Field

脂質代謝

Academic Significance and Societal Importance of the Research Achievements

心疾患は日本人の死因で悪性新生物についで2番目に多く、その中には動脈硬化が原因となる虚血性心疾患も多く含まれている。LDL-Cを上昇させる作用のあるPCSK-9の生理的役割については未だ解明されていないことも多い。また血清PCSK-9値が臨床的にどのような意味を持つのかはわかっておらず臨床応用されていない。そこで我々は「一般住民における血中PCSK-9濃度測定は心血管イベントの予知因子となるか」をテーマに研究を行いPCSK-9の生理的役割および、動脈効果との関連の解明の一助となり動脈硬化疾患の予防の幅が広がる可能性があると考え研究を行った。