Dementia prevention within the ageing Japanese society

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K19449
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: National Cancer Center Japan
• Principal Investigator: Abe Sarah 国立研究開発法人国立がん研究センター, がん対策研究所, 研究員 (60739530)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: Dementia / Ageing / Epidemiology / Nutrition

Outline of Final Research Achievements

The underlying purpose of the study remained to explore risk factors of dementia with a slight shift in the focus due to feasibility. The main risk factors analysed in the study were polyunsaturated fatty acids (PUFA) and fish intake and risk of disabling dementia. Total n-3 and n-6 PUFA and as well as n-3 PUFA eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and alpha-linolenic acid (ALA) and the risk of disabling dementia were analysed in multivariable Cox proportional hazard models to obtain hazard ratios (HR) and 95% confidence intervals (CI) . The manuscript is currently being submitted to a journal for peer review and concrete results of the study will therefore not be released in this report.

Free Research Field

Public Health

Academic Significance and Societal Importance of the Research Achievements

Prioritizing dementia research, diagnosis and control is a public health priority. We expect that using reliable data from a large-scale Japanese cohort will contribute to Japan’s dementia-related goals established by the Ministry of Health Labor and the WHO’s global dementia goals.