Complications and correlations of bone, joint, and muscle diseases in hip joint -The ROAD study-

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K19454
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: The University of Tokyo
• Principal Investigator: Iidaka Toshiko 東京大学, 医学部附属病院, 特任助教 (80800680)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 変形性股関節症 / 骨粗鬆症 / サルコペニア / コホート / 要介護

Outline of Final Research Achievements

In this study, we revealed the interrelationships between three conditions affecting the elderly's walking ability - osteoporosis of the femoral neck (OP), osteoarthritis of the hip (OA), and lower limb sarcopenia (LLS) - as well as their associations with the need for long-term care using a large-scale nationwide cohort study of bone and joint disease called Research on Osteoarthritis/osteoporosis Against Disability (ROAD). LLS was defined using lower limb muscle mass, quadriceps femoris muscle strength, and gait speed. Regarding the interrelationships among OP, OA, and LLS, LLS showed a significant association with OP. Although the three conditions tended to increase the risk of long-term care needs, no significant associations were found. On the other hand, the presence of decreased quadriceps femoris muscle strength significantly increased the risk of long-term care need.

Free Research Field

整形外科

Academic Significance and Societal Importance of the Research Achievements

ROADスタディは運動器疾患を予防目的とした地域住民コホートとしては世界最大規模であり、また骨、関節、筋肉すべての運動器にわたり検査や測定を実施しているため、これらの相互関係を解明できるところが大きな利点である。要介護予防の観点からは、歩行能力に直結する大腿部の骨、関節、筋肉の関連を解明することが必須であり、本研究により相互関連、合併率と予後との関連が明らかになれば、要介護移行への精度の高い効率的な予防につながり、高齢者の介護予防、QOLの増進に大きく貢献できると確信している。