Association of obstructive sleep apnea with cognitive and physical function, and silent cerebral lesions in female Japanese general population: a cross-sectional study.

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K19457
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Torii Sayuki 滋賀医科大学, 医学部, 特任助教 (30773973)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 疫学 / 日本人一般住民女性 / 睡眠時無呼吸 / 無症候性脳血管障害 / 認知機能 / 身体機能

Outline of Final Research Achievements

We conducted a cross-sectional study in a population-based sample of apparently healthy Japanese women to examine the prevalence of obstructive sleep apnea (OSA) and the association of OSA with cognitive function, physical function and silent cerebral lesions (lacunar infarcts, microbleeds, white matter hyperintensities and brain artery stenoses) evaluated by brain magnetic resonance imaging. SESSA Women study was randomly recruited community dwelling women in Japan. 610 women aged 60 to 85 years was measured oxygen saturation level at sleep. We defined 3% ODI (Oxygen Desaturation Index) ≧5 as breathing-related sleep disorder. We excluded 40 women those with missing information. Thus, 570 women were included in this analysis. Among them, 276 women (48.4%) had mild OSA. These results indicated that 48.4% of Japanese elder women (aged 60 to 85) will have mild breathing-related sleep disorder including OSA.

Free Research Field

循環器疾患予防医学

Academic Significance and Societal Importance of the Research Achievements

日本人の地域一般住民において、睡眠時無呼吸を含む睡眠呼吸障害群における認知機能、身体機能、ラクナ梗塞、微小脳出血、白質病変、脳動脈狭窄などの無症候性脳血管障害の状況について横断的に検討することができた。現段階では睡眠呼吸障害と各指標との関連について詳細な検討までは行えていないため、今後さらなる解析・検討を行う予定である。これらにより、睡眠呼吸障害と認知症・脳卒中・フレイルの関連について詳細な疫学分析に基づいたわが国独自のエビデンスの創出が期待される。本研究はコホート研究でもあり、今後は心血管疾患の発症や死亡との関連についてのさらなる検討も可能である。