Relationship between handgrip strength and incident metabolic syndrome in a Japanese urban cohort: the Suita Study

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K19475
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Kohmo Kyoko 国立研究開発法人国立循環器病研究センター, 病院, 医師 (40784153)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: muscle strength / handgrip strength / muscle / fat / diabetes

Outline of Final Research Achievements

Sarcopenia is diagnosed by the presence of low muscle strength or low physical performance in addition to low muscle mass. Although there have been some reports about the association of sarcopenia with diabetes in cross-sectional investigation, the previous studies lacked the evidence about the association of sarcopenia with incident diabetes in longitudinal study. We prospectively followed 2643 Japanese urban people (1088 men and 1555 women) from the Suita Study initially free of diabetes on the examination in 2005 and 2006. During an average of 8.0 years follow-up until 2018, 222 diabetes cases (118 men and 104 women) occurred. This study revealed that elevated body fat percentage was associated with increased incident diabetes risk and elevated non-fat percentage was associated with decreased risk.

Free Research Field

Preventive medicine

Academic Significance and Societal Importance of the Research Achievements

糖尿病患者の診療では、血糖管理目的で、体脂肪量を減らし骨格筋量を増加させるよう指導が行われている。本研究の研究成果により、今後は、糖尿病でない者においても将来的な糖尿病発症を予防する目的で、同様の指導が行われることが期待される。また、一般に腹囲やBMIを目安に健康管理が行われているが、本研究により、体脂肪量や骨格筋量などの体組成を考慮した管理も合わせて重要であることが分かった。