Electric field and effect on the neuroinflammation-mitochondrial activity of transcranial direct current stimulation.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K19792
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Bunai Tomoyasu 浜松医科大学, 光尖端医学教育研究センター, 特任助教 (20754188)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: tDCS / PET / ミトコンドリア活性

Outline of Final Research Achievements

Transcranial direct current stimulation (tDCS) has been reported to promote cognitive function, but its neuroscientific basis has not been fully investigated. The effect of tDCS on mitochondrial activity was investigated using PET.
We evaluated the binding potential images of [18F] BCPP-EF that label the mitochondrial electron transport chain enzyme complex I and investigated the relationship between tDCS and mitochondrial activity. A cognitive function test was also performed.
tDCS increased mitochondrial activity in the left insular cortex and lateral orbitofrontal cortex. tDCS improved the correct word answer of Operation Span Task and the accuracy of Reaction Time.

Free Research Field

脳神経内科

Academic Significance and Societal Importance of the Research Achievements

本研究により、経頭蓋直流電気刺激(tDCS)が神経伝達物質のみでなく、ミトコンドリア活性という脳内環境にも作用していることを確認できた。脳内におけるミトコンドリア活性の異常や機能障害は、発達障害やパーキンソン病など精神神経疾患で報告されている。tDCSはその簡便性から、今後多くの疾患への治療応用が検討されている。本研究は、tDCSを精神神経疾患への治療応用を検討していく神経科学的な基盤になると考えられた。