2020 Fiscal Year Final Research Report
Development of a method for extending the effect of botulinum therapy by inhibiting nerve regeneration
| Project/Area Number |
19K19794
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Keywords | ボツリヌス療法 |
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| Outline of Final Research Achievements |
Spasticity is one of the abnormal symptoms of muscle tension caused by a brain disease such as cerebral stroke and botulinum therapy is a treatment that relieves spasticity by intramuscular injection. The purpose of this study is to establish a method for extending the duration of the effect of botulinum therapy. The combined use with anti-IGF1R antibody, which is related to nerve regeneration factor, resulted in a short-term prolongation of the effect in experiments on mice.
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| Free Research Field |
リハビリテーション
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| Academic Significance and Societal Importance of the Research Achievements |
ボツリヌス療法は脳梗塞を始めとする脳の疾患によって生じる、痙縮に対して行われる治療である。効果の有用性がある一方で、効果の持続期間が限られており、持続時間延長が望まれている。
本研究は健常マウスを使用した実験で、抗体を併用することでボツリヌス療法の効果持続期間を延長する方法を示すものである。痙縮治療発展のための礎となる研究である。
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