Effects of exercise training on oxidative stress in the cardiorenal syndrome.

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K19801
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Tohoku Medical and Pharmaceutical University
• Principal Investigator: Takahashi Asako 東北医科薬科大学, 医学部, 講師 (20825773)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 食塩感受性高血圧 / Dahl食塩感受性ラット / 腎保護作用 / 運動 / 脂肪酸β酸化 / ミトコンドリア

Outline of Final Research Achievements

We examined the effects of chronic exercise on the heart on cardiorenal syndrome using chronic renal failure rats with 5/6 nephrectomy rats, which are chronic renal failure model. Exercise significantly suppressed left ventricular fibrosis, reduced the expression of renin-angiotensin system proteins and oxidative stress in the hearts of chronic renal failure rats with 5/6 nephrectomy.
We also examined the effects of chronic exercise on mitochondrial function in the kidneys of Dahl salt-sensitive rats, which are also used as a heart failure model. Exercise significantly improved renal function and significantly increased the renal expression of fatty acid β-oxidation enzymes, their transcription factors PPARα and PCG-1α, and the electron transport chain complexes.

Free Research Field

リハビリテーション、内部障害

Academic Significance and Societal Importance of the Research Achievements

長期的運動が腎不全モデルラットの心臓において酸化ストレスを軽減することが示された。また、長期的運動が、ミトコンドリア脂肪酸β酸化や電子伝達系に関わる酵素の発現を増加させるとともに腎機能を改善させることも明らかになった。長期的運動による腎保護効果と心腎連関のメカニズムをさらに解明することで、慢性腎臓病患者や慢性腎臓病を合併する慢性心不全患者の予後改善、透析導入予防や導入時期遅延に有効な運動療法の開発および普及、薬物療法との併用の提案、ひいては医療経済的にも大きな恩恵をもたらす可能性があると考える。