Development of life habit improvement instruction system by [visualization] of salt intake and sedentary time

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K19840
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Dokkyo Medical University
• Principal Investigator: Asuka Ueno (栗原明日香) 獨協医科大学, 医学部, 助教 (50725546)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 生活習慣 / 減塩 / 運動 / 座位時間

Outline of Final Research Achievements

Sedentary behavior may be an independent risk factor for cardiovascular events.This study aimed to clarify the effects of extended sedentary time in patients with diabetic kidney disease (DKD) on the risk of all-cause death and new events. A prospective cohort study was performed over 39 months. The study included 173 patients with DKD who completed the International Physical Activity Questionnaire (101 men;mean age,71±11 years).Data were analyzed using a multivariate Cox proportional hazard regression model with variables, including sedentary time. There were 34 cases of new events during the observation period, including 4 cases of stroke, 20 cases of CVD, 4 cases of HD implementation, and 6 cases of death. Hazard ratio (HR) calculations for the new event onset group identified sedentary time as a significant independent variable. The independent variable that was identified as a significant predictor of new events was the sedentary time (60min/day;HR:1.23,95%CI:1.05-1.45,p=0.012).

Free Research Field

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Academic Significance and Societal Importance of the Research Achievements

糖尿病性腎症患者において、座位時間の延長は心血管イベントおよび全死亡リスクに関連し、予後悪化に関連する座位時間のカットオフ値を明らかにした。また、身体活動量や塩分摂取の見える化による具体的な指導を実践し、その有用性を明らかにした。以上より、予防医学的観点より座位時間減少に対する意義と解決のための指導方法について新たな知見が得られ、減塩や身体活動量の改善も加えた、包括的で有効な指導方法が明らかとなり、学術的意義は高く、糖尿病性腎症の進展予防を目指した本研究の社会的意義は高い。