Repetitive Peripheral Magnetic Stimulation for severe upper limb hemiparesis

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K19847
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Kinoshita Shoji 東京慈恵会医科大学, 医学部, 助教 (60748383)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 反復性末梢磁気刺激 / リハビリテーション / 上肢麻痺 / 脳卒中 / 脳血管障害

Outline of Final Research Achievements

The purpose of this study is to develop repetitive Peripheral Magnetic Stimulation (rPMS) therapy as an effective treatment for post-stroke upper limb paralysis. The study protocol was approved by an accredited clinical research review board as a multicenter randomized controlled trial and registered in the jRCT. Due to the new coronavirus infection, the accumulation of cases was delayed, and as a result, the study was terminated with the enrollment of 9 cases against the target number of 50 cases. Because there were not enough cases for statistical analysis, the efficacy and safety were not verified, but no adverse events occurred in either group.

Free Research Field

リハビリテーション医療

Academic Significance and Societal Importance of the Research Achievements

本試験では4800発群に3例、2400発群に3例、0発群に3例が登録され、治療が実施された。主要評価項目である治療開始前(0週、Day0)から治療2週後(Day14)の上肢機能(Fugl-Meyer Asessment)の変化量 は4800発群で3.0±1.0(平均±標準偏差)、2400発群で2.7±1.2、0発群で0.7±2.5の結果となった。統計解析に足りる症例を集積できていないことから有効性については検証しなかった。いずれの群においても有害事象は発現していなかった。しかし、 統計解析に足りる症例を集積できていないことから安全性については検証できていない