Exploratory study of rehabilitation during dialysis for hemodialysis patients with sarcopenia

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K19872
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Sapporo Medical University
• Principal Investigator: Koyama Masayuki 札幌医科大学, 医学部, 助教 (10822736)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: サルコペニア / リハビリテーション / 血液透析

Outline of Final Research Achievements

In Japan, where the population is aging rapidly, age-related muscle weakness (sarcopenia) and therapeutic intervention against it are attracting attention. The aging population in the field of dialysis, prolonged "bed rest" and "low nutrition" during dialysis are thought to be associated with muscle weakness, but detailed studies have not been conducted.
The investigators have previously studied the effects of rehabilitation and nutritional therapy during dialysis on hemodialysis patients with sarcopenia in a single-center cohort, and reported that the combination of both was effective. The main objective of this study was to expand a single group of intervention studies to a multicenter setting to determine feasibility and generalizability.

Free Research Field

循環器疫学、肺高血圧、透析領域、性差医療

Academic Significance and Societal Importance of the Research Achievements

本研究は「不動」を解消することに主眼を置き、誰もが受けられる簡便な方法で効果を検証した。さらに透析室を闊達な空間へリノベートするために、栄養療法を組み込んだパッケージ型の「透析リハ」を提唱する。CKD患者に対する腎リハから引き続き、切れ目ないリハビリテーションを展開することがで切れば、CKD進展の予防と透析導入の減少効果 (腎リハ効果) に、透析導入後の ADL 低下の予防効果 (透析リハ効果) が加わることで、健康寿命の延伸、医療費削減といった名目で世の中に大いなる波及効果が期待できる。