2021 Fiscal Year Final Research Report
Development of an effective intervention for ICU-acquired weakness focusing on repetitive continuous stretching
Project/Area Number |
19K19911
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 59010:Rehabilitation science-related
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Research Institution | Sapporo Medical University |
Principal Investigator |
Abe Masami 札幌医科大学, 保健医療学部, 研究員 (00829880)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | ICU関連筋力低下 / ストレッチ / メカニカルストレス |
Outline of Final Research Achievements |
In order to develop an effective intervention for ICU-acquired weakness (ICUAW), we investigated the effect of repetitive continuous stretching (RCS) on denervated rat skeletal muscle. Our results suggest that mechanical load induced by RCS inhibits post-synaptic dysfunction and hence an activation failure in early denervated skeletal muscle. Thus, RCS can be used to preserve muscle contractile function during early stage of ICUAW.
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Free Research Field |
筋機能制御学
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Academic Significance and Societal Importance of the Research Achievements |
ICUAWは全身性の筋力低下が生じ,生命予後の不良を招くことから,超急性期リハビリテーションの実施が推奨される.しかしながら,リスク管理やマンパワーの必要性から効果的な介入を行うことが困難である.本研究の成果は,RCSがICUAWを予防する可能性を示唆するとともに,ICUAWに限らず,特に周術期など,不活動によって筋力低下を呈する多くの患者に対しても,予後改善に寄与することが期待される.
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