Longitudinal changes of functional recovery in rat stroke model

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K19913
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Yokohama City University
• Principal Investigator: NAKAJIMA Waki 横浜市立大学, 医学研究科, 特任講師 (10737323)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: AMPA受容体 / 運動機能回復 / PET / 慢性期リハビリテーション

Outline of Final Research Achievements

In this study, a model of chronic internal hemorrhage was successfully created and the ability of motor function recovery after chronic rehabilitation was examined. A variability was observed in the ability of motor function recovery after chronic rehabilitation. Furthermore, we examined changes in AMPA receptor density in the brain using [11C]K-2, a positron emission tomography (PET) probe that labels AMPA receptors. We found that AMPA receptor density was highly accumulated in the motor cortex on the injured side. And we found that a correlation between AMPA receptor density and the ability of motor functional recovery. These results suggest that AMPA receptors play an important role in chronic rehabilitation.

Free Research Field

生理学

Academic Significance and Societal Importance of the Research Achievements

従来効果が減弱すると言われている慢性期リハビリテーション（リハビリ）によって、運動機能回復が認められた場合、シナプスで機能的に活躍するAMPA受容体の密度が増加していた。この事実は、慢性期リハビリにおいてもAMPA受容体密度変化が重要な役割を果たしていると考えられる。今後、脳卒中慢性期への新規治療介入や新規治療法の開発の可能性を示唆するものと考えられる。