Establishment of a new Parkinson's disease treatment by improving oxidative stress using rehabilitation

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K19920
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Takasaki University of Health and Welfare
• Principal Investigator: OHNO YOICHI 高崎健康福祉大学, 保健医療学部, 准教授 (10709059)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: パーキンソン病 / 酸化ストレス / 運動効果 / 動物実験

Outline of Final Research Achievements

Mitochondrial dysfunction due to oxidative stress has been reported to be a factor in the onset and progression of Parkinson's disease. This study was initially planned to verify the beneficial effect of exercise in reducing oxidative stress by intervention in patients. However, due to the impact of COVID-19, it became impossible to intervene in patients, so we focused on studies using animals.
As a result, we found that high-intensity exercise had the greatest impact on oxidative stress dynamics in the body. On the other hand, it was shown that the effects are not necessarily related depending on the indicators and samples to be measured. We believe that the results obtained in this animal experiment can provide basic information for examining the effects of oxidative stress in exercise interventions for patients with Parkinson's disease in the future.

Free Research Field

リハビリテーション

Academic Significance and Societal Importance of the Research Achievements

運動と酸化ストレスとの関係は多くの検討が行われているが、その効果は一定の見識が示されていない。本研究では運動強度の異なる高負荷運動と中等度負荷運動による介入が脳内活性窒素種および血中酸化ストレス、抗酸化力に与える影響を検証した。
その結果として、高負荷運動では脳内活性窒素種の低下、血中酸化ストレスの増加など様々な影響を示すに至った。このことは、パーキンソン病患者に対して酸化ストレスの改善効果を求めるためには、更なる運動方法等の検討の必要性を示すことが出来たものと考えている。