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2021 Fiscal Year Final Research Report

Regulatory mechanics for improving insulin sensitivity by a single bout of resistance exercise

Research Project

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Project/Area Number 19K20007
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionFukuoka University (2020-2021)
Kyoto University (2019)

Principal Investigator

Kido Kohei  福岡大学, スポーツ科学部, 助教 (50822730)

Project Period (FY) 2019-04-01 – 2022-03-31
Keywordsレジスタンス運動 / インスリン感受性 / 骨格筋 / AMPK / mTORC1 / IRS-1
Outline of Final Research Achievements

The purpose of this study was to elucidate a causal relationship between insulin-stimulated glucose uptake and activation of molecular signal following a single bout of resistance exercise. The present study demonstrates that resistance exercise increased skeletal muscle glucose uptake in response to insulin, which was suppressed by activation of mTORC1, a regulator of insulin resistance. It is known that mTORC1 activation after resistance exercise was reduced by fasting. Therefore, the present study examined the effect of fasting on resistance exercise-induced insulin sensitivity and demonstrated that fasting potentiated insulin sensitizing effect of resistance exercise.

Free Research Field

運動生理学、運動生化学

Academic Significance and Societal Importance of the Research Achievements

これまで、単回のレジスタンス運動が、その後のインスリン感受性に与える影響は明らかでなかった。つまり、本研究は、単回レジスタンス運動の実施が、インスリン感受性の改善に有効であることを初めて示した知見となった。運動の継続的な実施に抵抗感のある糖尿病患者にとっては、一回の運動が血糖コントロールの改善に効果的であるという知見は、運動実施意欲の維持、向上に繋がる。さらに、レジスタンス運動特異的な作用機序の一端を明らかにしたことは、患者の病態や投薬状況を考慮した運動種別の選択に貢献し、運動処方の臨床的汎用性を高める基礎データの構築に繋がった。

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Published: 2023-01-30  

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