Interrelationship between cardiovascular control and thermoregulation during exercise: understanding the mechanism mediating the individual differences and its applications

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K20034
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Akita University
• Principal Investigator: Watanabe Kazuhito 秋田大学, 教育文化学部, 講師 (70733145)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 暑熱ストレス / 運動 / 循環反応 / 体温

Outline of Final Research Achievements

Prolonged exercise in the heat can pose severe challenges to human cardiovascular control and thermoregulation. We investigated how cardiac output is determined under such a condition. We also examined the potential effects of core vs. peripheral temperatures on hyperthermia-induced hemodynamic responses. Findings of this study demonstrate that, during prolonged exercise in the heat, the combination of dehydration and hyperthermia leads to impaired cardiac output because of a reduced LV filling and venous return, but not intrinsic left ventricular function. Furthermore, they suggest that an increase in peripheral blood flow induced by passive hyperthermia is related to a change in peripheral tissue temperature rather than core temperature.

Free Research Field

運動生理学

Academic Significance and Societal Importance of the Research Achievements

本研究では、循環調節と体温調節に関する統合的検討から、暑熱下運動時の心拍出量応答には心機能ではなく血流動態に関わる因子が強く関与すること、また、深部体温よりも末梢の組織温度のほうが体温上昇に伴う血流応答に強く関係することが初めて示唆された。本研究の成果は、運動時における循環と体温の相互関係や循環応答に顕著な個人差が生じるメカニズムの解明に寄与するものであり、今後、運動の効果や安全性の向上等に応用するための基盤となる。