Elucidation of sweat gland aging using immortalized sweat gland myoepithelial cells.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K20113
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Osaka University
• Principal Investigator: Hayakawa Tomohisa 大阪大学, 薬学研究科, 特任助教(常勤) (60773132)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 老化 / 汗腺 / 細胞株

Outline of Final Research Achievements

The purpose of this study is the establishment of immortalized sweat gland myoepithelial cells for elucidating the mechanism of sweat gland aging. In this study, we succeeded in establishing the immortalized cells of sweat gland myoepithelial cells. These cells can be cultured for a longer period of time than normal sweat gland cells, indicating their usefulness as a test material in sweat gland study. In addition, the established cells were shown to have the differentiation potential, like primary myoepithelial cells. The outcomes related to this cell line have been published in a paper. Additionally, the patents related to this cell line had been applied. Moreover, we succeeded in selling of the cells worldwide.

Free Research Field

老化基礎科学

Academic Significance and Societal Importance of the Research Achievements

ヒトのように汗腺を体温調節に利用している生物は馬に見られる程度で哺乳類全体として珍しい機構と言える。そのため、ヒト汗腺の研究のための手法は限られていた。今回、我々の研究で樹立した不死化筋上皮細胞は3次元スフェロイド培養に対応できるため、より実際のヒト汗腺に近い試験モデルとなり得る。不死化筋上皮細胞は、今後の汗腺研究における汗腺機能の理解、また制汗製品の開発に寄与するものと言える。