Function of novel bifidbacteria on anti-obisity

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K20120
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Okayama Prefectural University
• Principal Investigator: Maruta Hitomi 岡山県立大学, 保健福祉学部, 助教 (30823231)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: ビフィズス菌 / 抗肥満 / 酢酸

Outline of Final Research Achievements

Obesity and type 2 diabetes are one of the most serious health problem worldwide. In recent years, it has been suggested that gut microflora is a contributing factor for the leading of obesity. Bifidobacterium, one of the gut microflora, produces acetic acid as a final metabolite. It has been indicated that supplementation of acetic acid has function of anti-obesity and antidiabetic. Therefore, in this study, we investigated novel function of Bifidobacterium, isolated from infant feces, which improve energy metabolism and prevent obesity. As a result, it was suggested novel Bifidobacterium was the strain having the potential to inhibit obesity and diabetes.

Free Research Field

栄養学

Academic Significance and Societal Importance of the Research Achievements

新たに単離したヒト成人の腸内にも生息するビフィズス菌種である新規ビフィズス菌株を摂取することにより、体重増加抑制や脂肪肝抑制などの肥満抑制効果があることを見出した。また、この作用機序は酢酸を摂取した際と類似しており、内因性の酢酸の効果であることが示唆された。糖尿病患者が増えている成人において、より適した新たなビフィズス菌の科学的な基礎知見となり、抗肥満効果という点で国民の健康増進に貢献できるものである。