The effects of dietary instruction on cardiovascular risk markers after smoking cessation : a multicenter randomized controlled trial

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K20139
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• Principal Investigator: komiyama maki 独立行政法人国立病院機構(京都医療センター臨床研究センター), 展開医療研究部, 主任研究員 (10771496)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 禁煙 / 体重増加 / 肥満 / 栄養指導 / 心血管リスク / アディポネクチン

Outline of Final Research Achievements

In this study, we conducted a multicenter trial to examine the effects of nutritional guidance on post-smoking weight, glucose/lipid metabolism, cardiovascular risk markers, and smoking cessation continuation rates for patients who gained weight after smoking cessation at smoking cessation outpatient clinics of the National Hospital Organization. This is a prospective randomized group-to-group parallel controlled trial. In this study, considering the burden on the patient, nutritional guidance was given three times 1, 4, and 7 months after registration. The primary endpoint is the blood level of adiponectin, which possesses anti-arteriosclerosis effects. The adiponectin level has been shown to increase with smoking and decrease with obesity, and is strongly associated with cardiovascular disease. Registration started at 5 facilities in April 2016, and as of May 12, 2021, a total of 54 people were registered.

Free Research Field

一般内科、予防医学、禁煙、肥満

Academic Significance and Societal Importance of the Research Achievements

禁煙後体重増加の予防により心血管リスクの更なる軽減が期待される。栄養指導は管理栄養士と共に食生活を見直し、肥満や病気の改善方法を考える場であり、医療経済効果も高い。禁煙後体重増加の予防に関し、女性に対する栄養指導は、禁煙後肥満の抑制や禁煙継続率向上に有用という報告はあるが、前向き比較試験は存在しない。本研究により、禁煙後体重増加および糖・脂質代謝マーカー悪化の予防を含めて包括的に心血管リスクを管理する、より質の高い禁煙治療指導要領の確立を行う。