Establishment of objective dietary survey method for prevention of lifestyle-related diseases by metabolome analysis

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K20153
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: The University of Shimane
• Principal Investigator: Tatano Hiroshi 島根県立大学, 看護栄養学部, 助教 (60825082)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 食生活 / メタボロミクス / 栄養学 / バイオマーカー

Outline of Final Research Achievements

In order to clarify the relationship between diet and disease, it is necessary to accurately assess dietary intake using objective indices because conventional subjective assessment may lead to errors. This study aims to establish an objective method for evaluating dietary intake by examining the temporal variation of metabolites that fluctuate specifically with food in vivo through a food loading test in healthy subjects. The results suggest that it is possible to evaluate meat and fish intake in healthy adult males by metabolites in blood and urine before and after intake. We will continue to examine foods other than meat and fish to establish an objective method for evaluating dietary intake.

Free Research Field

食生活

Academic Significance and Societal Importance of the Research Achievements

本研究で示唆された結果を元に、客観的な食事摂取の評価方法の確立ができれば、特定の代謝物を指標として食生活の把握ができるため、簡易キットなどで食生活の早期把握が可能となり、生活習慣病の一次予防に繋がることが考えられる。医療施設では、管理栄養士による栄養指導や医師による治療がより的確となり、生活習慣病発症リスクが軽減することが期待される。