Site determination and application of LTBP-1, a molecule related to arteriosclerosis, involved in cell migration

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K20157
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Chiba Institute of Science
• Principal Investigator: Mimori Seisuke 千葉科学大学, 薬学部, 講師 (70433688)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: LTBP-1 / 動脈硬化症 / TGF-β / 細胞遊走

Outline of Final Research Achievements

Atherosclerosis is the most common form of atherosclerosis, a collective term for several diseases that cause thickening and loss of elasticity of the arterial wall.
In this study, we attempted to identify the site where Latent TGF-β binding protein-1 ( LTBP-1 ), a component of the TGF-β complex, has a migratory effect on smooth muscle cells during the process of arterial intima-media thickening, which is currently the most widely accepted process in atherosclerosis. Furthermore, we would like to clarify the relationship between the function of LTBP-1 and TGF-β, and develop how it works in the onset, progression, and regression of atherosclerosis.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

アテローム性動脈硬化は，冠動脈疾患や脳血管疾患を引き起こすことから，動脈硬化症の中で最も重篤で臨床的に重要な病態でもある。アテローム性動脈硬化は、あらゆる大型および中型動脈に発生し、米国や多くの先進国において疾患発生および死亡の主な原因となっている。本研究のようにアテローム性動脈硬化において、LTBP-1に着目し、その病態との関係についての報告は少なく、まだ明らかになっていないことが多い。そのため新たな知見により創薬開発などにつながることが期待できる。