the elucidation of the mechanism of PEW onset in CKD

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K20167
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Konan Women's University
• Principal Investigator: Imi Yukiko 甲南女子大学, 医療栄養学部, 助手 (60823979)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 脂肪酸組成

Outline of Final Research Achievements

CKD patient often becomes the state known as protein-energy wasting (PEW) which shows depletion of whole protein and energy fuel such as fat. In this study, we investigated the effect of primary kidney dysfunction on lipid metabolism and fatty acid composition using adenine-induced CKD model rats to reveal the mechanism of PEW onset. Adenine intake induced marked reduction of body weight, fat mass, and hepatic lipid accumulation. Lipogenic genes expression was decreased and lipolytic genes expression was increased in the liver and white adipose tissue of adenine group. Fatty acid composition was changed by adenine. Monounsaturated fatty acid levels were decreased consistent with fatty acid desaturase expression in adenine group. Plasma unesterified fatty acid level was decreased in adenine group although lipolysis was enhanced. It is indicated that primary kidney dysfunction induced body fat reduction through by enhancing energy consumption.

Free Research Field

基礎栄養学

Academic Significance and Societal Importance of the Research Achievements

PEWはCKD患者において予後の悪化につながることから、その予防法や治療法の確立が求められる。PEW発症のメカニズムは摂食量低下による低栄養だけでなく炎症やインスリン抵抗性など様々な要因が関与していると考えられる。そのメカニズム解明や食事療法の開発には、実験動物を用いた検討が必要であり、本研究ではアデニン投与によるCKDモデル動物のエネルギー代謝や脂肪酸組成について示した。結果はこれまでヒトにおける報告と矛盾したものとなったが、モデル動物についての新たなデータを示した学術的意義のある成果となった。