Analysis of physiological roles of FABP5 in age-related chronic inflammation in adipose tissue

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K20172
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Kyoto Institute of Technology (2021-2022); National Center for Geriatrics and Gerontology (2019-2020)
• Principal Investigator: Kawaguchi Koichiro 京都工芸繊維大学, 応用生物学系, 講師 (10794274)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 慢性炎症 / 加齢 / 脂質代謝 / 脂肪酸 / 脂肪酸結合タンパク質

Outline of Final Research Achievements

To clarify the role of FABP5 in chronic inflammation of adipose tissue that develops with aging, we analyzed cultured cells and knockout mice. We revealed that FABP5 expression is mainly regulated by NFκB in 3T3-L1 adipocytes. In addition, the expression levels of IL-6, IL-18, etc. were decreased in adipose tissue derived from old FABP5 knockout mice. Since these inflammatory cytokines are regulated by NFκB, FABP5 could be involved in the regulation of NFκB signaling. Thus, it was suggested that chronic inflammation in aged adipose tissue may be due to the presence of an NFκB -FABP5 inflammatory activation loop.

Free Research Field

健康科学

Academic Significance and Societal Importance of the Research Achievements

我が国では超高齢化が進行する一方で、人口動態の劇的な変化は現状期待できない。したがって、がんや生活習慣病などの加齢性疾患に対する治療法や予防法の開発は、単に患者のQOL向上に貢献するだけでなく、社会全体の生産性向上ひいては我が国の国力増進につながる。本研究により得られた成果は、加齢性疾患の基盤病態である慢性炎症の病態解明に資するものである。今後さらに本研究を発展させることで、加齢性疾患の予防を通して超高齢化社会における高齢者の健康維持に寄与し、持続可能な少子・高齢化社会の構築が期待できる。