Insulin-like growth factor-1 and lipoprotein profile in small for gestational age mouse model

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K20194
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Nihon University
• Principal Investigator: NAGANO Nobuhiko 日本大学, 医学部, 准教授 (90794701)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: DOHaD / 非肥満 / マウスモデル / 子宮内虚血 / SGA / 高血糖 / インスリン抵抗性

Outline of Final Research Achievements

Low birth weight infants are at high risk of developing metabolic diseases due to changes in their constitution during gestational age. The pathophysiology of low birth weight-diabetes onset is not well understood without a suitable animal model. Therefore, we examined whether intrauterine ischemic mice could be a model for the development of non-obese and obese hyperglycemia. As a result, low birth weight pups were born due to intrauterine ischemia, and hyperglycemia developed in the adult stage (8 weeks of age) despite low weight on a normal diet after weaning. In addition, a high-fat diet developed obesity and marked hyperglycemia. We have succeeded in developing a mouse model with low birth weight and non-obese hyperglycemia (Japanese Patent Application No. 2020-116354). If the pathophysiology of this model can be elucidated, it will be possible to predict low birth weight infants at high risk of developing non-obese diabetes.

Free Research Field

新生児学

Academic Significance and Societal Importance of the Research Achievements

日本では総出生数は減少しているが低出生体重児は増加している。我が国では、その低出生体重児の将来の健康障害を減らすことが医療的・経済的・社会的に求められている。低出生体重児は、成人期の非肥満型糖尿病の発症リスクが高いが、低出生体重-糖尿病発症の病態は適切な動物モデルがなく十分に解明されていない。それゆえ、そのアニマルモデルの開発が喫緊の課題であった。今回開発した低出生体重-非肥満型高血糖発症マウスモデルの高血糖発症機序を解明し、新たな栄養法の開発ができれば、低出生体重児の成人期の非肥満型糖尿病を激減させることができる。その結果、低出生体重児の健康増進に大きく貢献できる可能性がある。