Elucidation of molecular mechanisms of metabolic disorder caused by excessive intake of fructose

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K20204
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: National Center for Global Health and Medicine
• Principal Investigator: Matsukawa Toshiya 国立研究開発法人国立国際医療研究センター, その他部局等, 研究員 (00817653)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: フルクトース / 代謝障害 / メタボリックシンドローム / 2型糖尿病 / 肥満 / 肝臓 / シグナル伝達

Outline of Final Research Achievements

This research investigated that the function of Aldolase B, has an important role in fructose metabolism, using Aldolase B KO mice to elucidate of molecular mechanisms of metabolic disorder caused by excessive intake of fructose.
Oxidative stress, is occurred by the metabolic disorder of fructose caused by excessive intake of fructose, which become a cause of metabolic disorders such as liver disorder and hypoglycemia. Additionally, KO mice increased the expression of target genes of ChREBP such as lipid synthesis-related genes. Furthermore, oxidative stress caused by fructose metabolic disorders could be improved by treatment with antioxidants. These results suggested that antioxidants may become an effective tool for treatment and or care of metabolic disorders such as metabolic syndrome.

Free Research Field

栄養生化学

Academic Significance and Societal Importance of the Research Achievements

フルクトースの代謝障害によって惹起される酸化ストレスは抗酸化剤の処理で改善できることから、今後、詳細な解析は必要ではあるがメタボリックシンドロームなどのフルクトースの代謝障害に対して疾患の治療・予防に対して抗酸化剤が有効な治療法の一つになる可能性が示唆された。また、抗酸化剤は遺伝的なフルクトース代謝障害であるフルクトース不耐症の新たな治療法の一つになる可能性も示された。