Elucidation of the mechanism of radiation-induced nitric oxide-induced aging of vascular endothelial cells

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K20452
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 63020:Radiation influence-related
• Research Institution: Azabu University
• Principal Investigator: Nagane Masaki 麻布大学, 獣医学部, 講師 (10772064)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 放射線被ばく / 細胞老化 / 血管内皮細胞 / 一酸化窒素

Outline of Final Research Achievements

Radiation-induced cardiovascular disease is potentially lethal and represents an important concern in radiotherapy and radiation exposure managements. In addition, cellular senescence of vascular endothelial cells is thought to be closely related to radiation-induced cardiovascular diseases, but the molecular mechanism is unknown. The purpose of this study was to elucidate the mechanism of cellular senescence induced by radiation-induced NO As a result of this project, it was found that nitric oxide production in response to DNA damage affects intracellular lipid and cholesterol metabolism.

Free Research Field

放射線生物学

Academic Significance and Societal Importance of the Research Achievements

放射線による心疾患は致死性が高く、放射線治療と被ばく管理において重要な課題となる。また、放射線による心血管疾患に、血管内皮細胞の細胞老化が深く関わると考えられるが、その分子機構は不明である。本研究の目的は、被ばくによる心血管疾患の病態解明を目指し、放射線誘導性NOによる細胞老化機構の解明である。本研究の成果は、放射線による心血管疾患の病態機構の解明のため重要な知見となる。