2021 Fiscal Year Final Research Report
Searching for fusion genes in neutron irradiation-induced lung cancer.
| Project/Area Number |
19K20454
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 63020:Radiation influence-related
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| Research Institution | National Institutes for Quantum Science and Technology |
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Principal Investigator |
SUZUKI Kenshi 国立研究開発法人量子科学技術研究開発機構, 放射線医学研究所 放射線影響研究部, 研究員 (20726442)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 融合遺伝子 / 中性子線 / 肺がん / 放射線 / マウス |
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| Outline of Final Research Achievements |
We have conducted large-scale irradiation experiments on mice using various types of radiation and have stored mouse lung cancer samples obtained from these experiments. In this study, we selected lung adenocarcinomas from unirradiated or irradiated groups and searched for fusion genes by RNA sequence analysis of these samples. As a result of the analysis, we were able to identify a number of candidate fusion genes in lung cancers from irradiated group. In the future, we plan to select from among these candidates those that actually function in oncogenesis and to characterize the genomic sequence patterns that tend to give rise to fusion genes. We are also planning to analyze the functional characteristics of the genes, such as how they are involved in the growth of lung cancer.
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| Free Research Field |
放射線生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、放射線誘発がんのアーカイブとして整理、保存してきた線量評価が確実かつ発がん要因の明確な動物個体に生じたがんを解析することに特色がある。様々なモデル動物に誘発された腫瘍を体系的に保存したアーカイブは、世界的にも他に類を見ないものであるが、特に中性線照射実験によって得られたサンプルは、照射出来る施設の希少性からも、国内外を通して非常に貴重なものとなっている。非照射群と中性子線照射群に生じた腫瘍との比較解析により、被ばくに特異的なゲノム異常や発がんメカニズムの存在を探索できるという意味で本研究の持つ学術的意義は大きい。
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