2019 Fiscal Year Research-status Report
Personalizing Brain Stimulation Dosage by New Neurostimulation Computational Model
| Project/Area Number |
19K20668
|
|---|
| Research Institution | Nagoya Institute of Technology |
|---|
Principal Investigator |
ゴメスタメス ホセデビツト 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (60772902)
|
|---|
| Project Period (FY) |
2019-04-01 – 2022-03-31
|
| Keywords | Brain stimulation / TMS / Multiscale modeling / Electric field / Nerve Modelling / Electroceuticals |
|---|
| Outline of Annual Research Achievements |
Transcranial magnetic stimulation (TMS) induces a neurostimulation dosage (i.e., electric field) in the brain via a magnetic coil placed over the scalp. A multiscale electrophysiological model was developed to describe how TMS-induced dosage interacts with the activation of brain circuits in the human cortex.
By using the proposed computational approach, this study investigated the induced electric field effects on large pyramidal brain neurons. Also, the stimulation intensity thresholds for activation were identified. The model was used to investigate the conservativeness of safety limits in international safety guidelines/standards for electromagnetic exposure. The results have practical implications in clinical practice for optimized brain stimulation and understanding TMS mechanism.
|
| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
Most of the contents described in the plan were achieved.
|
| Strategy for Future Research Activity |
In FY2020, experiments of TMS physiological responses will be conducted to validate and improve the multiscale electrophysiological model. TMS-induced currents in the human motor cortex can target specific brain circuits according to the stimulation conditions that can generate different responses. The model developed will be used to determine neuronal responses using the same experimental setup (coil position/orientation and stimulation strength) and a realistic head model of the subjects. For the first one, a navigation system will record the position/orientation of the coil. For the second one, magnetic resonance images of each subject will be obtained to construct individualized head models.
|
