2021 Fiscal Year Annual Research Report
Personalizing Brain Stimulation Dosage by New Neurostimulation Computational Model
| Project/Area Number |
19K20668
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
ゴメスタメス ホセデビツト 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (60772902)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | Brain stimulation / TMS / Multiscale modeling / Electric field / Nerve Modelling / Electroceuticals |
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| Outline of Annual Research Achievements |
Transcranial magnetic stimulation (TMS) modulates brain activity by an induced electric current via a magnetic coil placed over the scalp. This study investigated how TMS-induced electric currents interacts with the complex circuitry of the human cortex, with the aim of determining the optimal stimulation parameters.
In the first year, a multiscale electrophysiological model was developed to estimate the induced electric current in a volume conductor of the human head, considering the electrical and anatomical properties of the tissues. The stimulation of the induced electric current on the brain motor cortex was implemented. The computational results were compared with measured stimulation thresholds of TMS eliciting motor responses. We found a significant correlation between experimental and estimated thresholds using individualized computational models while identifying the stimulation site with greater detail.
In the last year, optimal stimulation parameters were determined in different motor brain areas, including upper and lower limb muscles. Finally, the developed techniques were extended to explore better selectivity protocols for brain stimulation and investigate the conservativeness of safety limits in international safety guidelines/standards for electromagnetic exposure. The results were published in top journals and international conferences in the field.
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Research Products
(9 results)
