2021 Fiscal Year Final Research Report
Personalizing Brain Stimulation Dosage by New Neurostimulation Computational Model
| Project/Area Number |
19K20668
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | Brain Stimulation / Neuron / Biophysical Model / Electromagnetics |
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| Outline of Final Research Achievements |
Electric currents are induced in the brain using stimulation devices for medical applications. This work estimated the interaction between the induced electric currents and brain neurons during magnetic stimulation. A novel computational model was developed that combined (1) computation of induced electric currents in the human head based on electrophysiological properties and anatomical data from magnetic resonance imaging and (2) cortical neuron activation based on microscopic biophysical modelling. The model successfully predicted the stimulation parameters and stimulation area in the brain for generating measured motor responses. This permitted optimization of stimulation parameters for different motor brain areas, improvement of selectivity protocols, and evaluation of limits for international safety guidelines/standards.
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| Free Research Field |
Neural Engineering
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| Academic Significance and Societal Importance of the Research Achievements |
This research answered where and how much stimulation occurs at the cellular level during brain stimulation. This finding will directly apply to medical treatments through individualized stimulation protocols that will accelerate the development of brain stimulation protocols.
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