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2022 Fiscal Year Final Research Report

Pathophysiology of Electrocardiographic Abnormalities in Duchenne Muscular Dystrophy

Research Project

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Project/Area Number 19K20673
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionNagahama Institute of Bio-Science and Technology (2021-2022)
Kobe University (2019-2020)

Principal Investigator

yamamoto tetsushi  長浜バイオ大学, バイオサイエンス学部, 准教授 (50650892)

Project Period (FY) 2019-04-01 – 2023-03-31
KeywordsDuchenne型筋ジストロフィー / 18誘導心電図 / 心機能低下 / 心臓超音波検査
Outline of Final Research Achievements

Duchenne muscular dystrophy (DMD) is an inherited muscle disease characterized by progressive and fatal muscle weakness. Using 18-lead ECG, which allows detailed observation of the right ventricle and posterior wall of the left ventricle, we investigated the relationship between V1 to V9 waveforms over time and cardiac function measured by echocardiography in DMD patients. This indicates that electrical impairment of the myocardium in the left ventricular lateral to posterior wall precedes cardiac dysfunction.

Free Research Field

循環器

Academic Significance and Societal Importance of the Research Achievements

Duchenne型筋ジストロフィー(DMD)を対象に、右室や左室後壁の詳細な観察が可能である18誘導心電図を用い、DMD患者のV1~V9波の経年変化と、心臓超音波検査で測定した心機能の関連を調べた結果、①心機能が低下する2年前にすでに心電図が変化していること、②その変化はV6~V9誘導で顕著であることより、心電図変化を観察することで簡便な心筋障害の予測マーカーとなる。また、特殊な心電図を用いなくとも多くの施設で行われている標準12誘導心電図のV6で観察でき、今後のDMDの心臓管理に役立つ。

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Published: 2024-01-30  

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