2020 Fiscal Year Final Research Report
Micro-scale, in-vivo structural and functional tomography of rodent habenula using polarization-sensitive optical coherence tomography
| Project/Area Number |
19K20674
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Keywords | Optical Imaging |
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| Outline of Final Research Achievements |
Habenula is a tiny anatomical structure that links the forebrain to the midbrain which regulates pathways associated with a range of behaviors including reproductive behaviors, central pain processing, nutrition, sleep-wake cycles, stress responses, and learning with lateral and medial habenula showing differences in connectivity and function.
The proposed research aimed at developing an imaging tool for volumetric assessment of small brain structures like habenula with high resolution.
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| Free Research Field |
Biomedical Engineering
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| Academic Significance and Societal Importance of the Research Achievements |
The proposed research developed a cost-effective 3-dimensional (3D) imaging tool that allows for high-throughput and high resolution imaging of brain structures. Serial imaging allows for easy 3D reconstruction for macroscopic quantitative analysis based on the high resolution brain imaging data.
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