Development of heart failure home monitoring utilizing urinary natriuretic peptides

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K20724
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 90130:Medical systems-related
• Research Institution: University of Toyama
• Principal Investigator: Kataoka Naoya 富山大学, 学術研究部医学系, 助教 (10791634)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 心不全 / ナトリウム利尿ペプチド / 非侵襲的バイオマーカー

Outline of Final Research Achievements

The present study aimed to development a new monitoring system of heart failure utilizing urinary natriuretic peptides. Firstly, we tried to newly develop a sandwich ELISA for measuring urinary N-terminal pro-brain natriuretic peptides (NT-proBNP). Although a commercially available ELISA kit for NT-proBNP could be obtained, some urinary NT-proBNP levels were lower than the sensitivity. Therefore, we treated NT-proBNP with deglycosylation and the urinary levels were two to three folds compared with those without deglycosylation. Moreover, we found that urinary NT-proBNP fluctuates along with heart failure compensation.

Free Research Field

循環器病学

Academic Significance and Societal Importance of the Research Achievements

本研究では、将来的な在宅モニタリングの機器開発へ向けて、基盤的研究成果が得られた。本研究で得られた尿中NT-proBNPの濃度分布や、脱糖鎖処理によって変動する濃度、また血行動態と共に尿中NT-proBNPも変動しうる事は、将来的な非侵襲的バイオマーカーの確立や在宅管理への応用に向けて有意義な結果となった。