Risk assessment of bronchoalveolar lavage and development of novel bronchoalveolar lavage method using a balloon catheter

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K20727
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 90140:Medical technology assessment-related
• Research Institution: Chiba University
• Principal Investigator: Abe Mitsuhiro 千葉大学, 医学部附属病院, 助教 (10769623)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 気管支肺胞洗浄 / バルーンカテーテル / 間質性肺炎 / 急性増悪

Outline of Final Research Achievements

(1) We retrospectively revealed that PaO2 less than 75 mmHg, BAL neutrophil fraction 7% or more,% DLCO less than 50%, GAP stage III, and BAL recovery rate less than 30% are risk factors for the onset of acute exacerbation.
(2) We retrospectively revealed that male, 65 years orlder, left bronchus, except for middle lobe/lingula, FEV1/FVC less than 80% are risk factors for poor recovery rate of BAL.
(3) Our prospective clinical trial revealed that BAL performed using a balloon catheter could not improve the recovery rate.

Free Research Field

びまん性間質性肺炎

Academic Significance and Societal Importance of the Research Achievements

①急性増悪発症の危険因子として、PaO2 75mmHg未満、BAL中好中球分画7%以上、%DLCO 50%未満、GAP stage III、BAL回収率30%未満が示された。なかでもBAL回収率不良が急性増悪の危険因子であることは世界で初めての知見である。
②BAL回収率不良の危険因子として、男性、65歳以上、左気管支、中葉・舌区以外、FEV1/FVC 80%未満が示された。
③バルーンカテーテルを用いても回収率の向上は難しいことが分かった。