Establishment of animal hemorrhage model and assesment of efficiency of novel hemostat

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K20732
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 90140:Medical technology assessment-related
• Research Institution: Osaka City University
• Principal Investigator: Arima Hironori 大阪市立大学, 大学院医学研究科, 講師 (10817729)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 止血材 / ゼラチン / 架橋

Outline of Final Research Achievements

This study was conducted to create an clinically highly functional and inexpensive hemostatic material by using crosslinked collagen as a hemostatic material. In the animal experimental model, it was confirmed that the new hemostatic material could shorten the bleeding time as compared with the control group. After subcutaneous implantation, there was almost no inflammatory reaction and its smooth absorption showed its good biocompatibility . In addition, a good function as a hemostatic material was confirmed in a test of physical examination using an electron microscope and a viscoelasticity measuring instrument.
The functional evaluation and evaluation of physical characteristics of the hemostatic material in this study will contribute to the reliable implementation of hemostasis in the field of surgery, and as a result, will contribute to the implementation of safe surgery. It can also contribute to reducing medical costs depending on the situation.

Free Research Field

脳神経外科　外科一般

Academic Significance and Societal Importance of the Research Achievements

動物を用いた多くの出血実験では、動物種・出血部位・測定方法は様々でかつ血圧管理がされておらず客観性に乏しい。一方で、本研究で作成した動物実験モデルは客観的かつ再現性のある方法での出血モデルであり、小動物を用いた出血実験の際には標準的に使用できる方法であると考える。また現行の止血材は高価なものがほとんどで臨床で使う際には量が不十分となることが多いが、本止血剤は安価に調整が可能である。その機能についても止血・生体適合性・物理特性いずれも臨床的に使用する上で有用な機能を確認でき、外科領域において安全・安価な止血材を提供するための多くのデータを取得できた。