2021 Fiscal Year Final Research Report
Development of a new preventive method for incontinence-associated dermatitis in the elderly: focusing on urea degradation by bacteria
| Project/Area Number |
19K20756
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| Project/Area Number (Other) |
17H06648 (2017-2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2017-2018) |
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| Research Field |
Gerontological nursing
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Mugita Yuko 東京大学, 大学院医学系研究科(医学部), 助教 (00804874)
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| Project Period (FY) |
2017-08-25 – 2022-03-31
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| Keywords | 失禁関連皮膚炎 / アンモニア / 尿素分解酵素 / 細菌 / 尿素 / 失禁 / 皮膚生理機能 / パッド |
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| Outline of Final Research Achievements |
The goal of this study was to establish a new method to prevent incontinence-associated dermatitis by focusing on urea degradation by bacteria.
We tested the effect of adding an antimicrobial agent and a urease inhibitor on the inhibition of urea degradation by bacteria (in vitro experiments). The results suggested that the addition of both antimicrobial agents and urease inhibitors above a certain concentration suppressed ammonia production by urea degradation and may contribute to the suppression of skin and pad pH elevation.
We also verified the performance of a prototype pad based on the concept of inhibiting urea degradation by bacteria (in vitro experiment). The results showed that the pads' antimicrobial performance and ability to inhibit pH elevation were confirmed up to 4 hours after urine containing bacteria was absorbed by the pads. Important finding that could lead to the development of new pads for the prevention of incontinence-associated dermatitis were obtained.
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| Free Research Field |
創傷看護学、看護理工学
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| Academic Significance and Societal Importance of the Research Achievements |
高齢者は失禁を有する方が多く、また、皮膚構造の変化に伴う皮膚機能の低下も有することから、高齢者はIAD発生リスクが極めて高い。実際、失禁を有する高齢者のIAD有病率は高く、有効な予防法の開発が喫緊の課題である。
本研究では、IAD予防に効果的なパッドを開発する基盤として、尿素分解によるpH上昇を抑制するというコンセプトの有効性を明確化した。今後、このコンセプトに基づき開発された新たなパッドの使用により、失禁を有する高齢者におけるIAD発生率あるいは重症度が低減することが予想される。IAD予防における新たな介入方法を臨床に提示することができ、IADに苦しむ高齢者の利益に直接貢献できると期待される。
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