Effect of hepatic dysfunction on the pathophysiology of uterine inflammatory diseases in cows.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K21166
• Project/Area Number (Other): 18H06029 (2018)
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund (2019); Single-year Grants (2018)
• Review Section: 0605:Veterinary medical science, animal science, and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: Magata Fumie 東京大学, 大学院農学生命科学研究科(農学部), 助教 (50635208)
• Project Period (FY): 2018-08-24 – 2022-03-31
• Keywords: 炎症性子宮疾患 / 肝機能障害 / リポポリサッカライド / 遊離脂肪酸 / ケトン体 / 卵胞 / 卵母細胞 / 乳牛

Outline of Final Research Achievements

The objective of this study was to elucidate the effect of hepatic dysfunction on the pathogenesis of uterine inflammatory diseases in dairy cows. The study demonstrated that uterine inflammation and hepatic dysfunction frequently coexisted in high-producing cows. The hepatic dysfunction may alter the follicular microenvironment and increase follicular fluid concentrations of bacterial toxins derived from uterine inflammation, resulting in ovarian dysfunction. These results indicate the association between uterine inflammation and hepatic dysfunction at the follicular level. Furthermore, the development of rat models of the disease enabled the detailed examination of metabolic diseases and reproductive dysfunction individually and in combination.

Free Research Field

家畜繁殖学

Academic Significance and Societal Importance of the Research Achievements

炎症性子宮疾患および肝機能障害に関する研究の多くは対症療法の開発を中心とした臨床学的検討であり，双方からのアプローチによる分子レベルでの病態解明は行われていなかった。本研究により，高泌乳牛において多発する肝機能障害と炎症性子宮疾患は相互に連関を示し，卵胞内微小環境を変化させることで卵巣機能障害を引き起こす可能性が示された。本研究成果は新たなアプローチによる革新的な治療法の開発のための基礎的知見となり，乳肉牛の生産性向上に寄与することが期待される。