2020 Fiscal Year Final Research Report
The change of neural directed network in human physiological and pathological states
| Project/Area Number |
19K21210
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| Project/Area Number (Other) |
18H06087 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0704:Neuroscience, brain sciences, and related fields
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| Research Institution | Kyoto University |
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Principal Investigator |
Usami Kiyohide 京都大学, 医学研究科, 特定助教 (20829204)
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| Project Period (FY) |
2018-08-24 – 2021-03-31
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| Keywords | brain waves / oscillation / 意識 / 睡眠 / electrocorticography / high-gamma activity / ネットワーク解析 / effective connectivity |
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| Outline of Final Research Achievements |
We applied single-pulse electrical stimulation (SPES) to the cortices in patients implanted with subdural electrodes during sleep and recorded SPES-elicited electrical signals. Then the spread pattern of neuronal activities indexed by high-gamma activity were analyzed between electrodes by event-related causality (ERC) method. We observed greater propagation of activity from frontal to parietal lobe during slow-wave sleep, and decreased propagation within frontal lobe, but increased propagation within parietal lobe, during REM sleep. We applied the analysis program used for this study to the other study, revealing spread of neuronal signals during a picture naming task.
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| Free Research Field |
神経生理学
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| Academic Significance and Societal Importance of the Research Achievements |
脳内有向ネットワークの生理的変容の一端を明らかにし，睡眠がヒト脳にもたらす影響の科学的解明に貢献した．さらに，本研究は，てんかんなどの病態脳のネットワーク変容を理解するうえでの基礎的データになると考えられた．また社会的意義としては，本研究をもとにシンポジウム講演，教育講演，総説の執筆を行い，幅広い領域へ睡眠を含む脳内ネットワークへの興味を喚起することに貢献できた．
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