2018 Fiscal Year Annual Research Report
Mechanism, evolution and regulation of multidrug resistance
| Project/Area Number |
18H06103
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| Allocation Type | Single-year Grants |
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| Research Institution | Osaka University |
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Principal Investigator |
ZWAMA MARTIJN 大阪大学, 産業科学研究所, 特任助教(常勤) (40827052)
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| Project Period (FY) |
2018-08-24 – 2020-03-31
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| Keywords | RND / Transporter / Antibiotic / Resistance / AcrB / Evolution |
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| Outline of Annual Research Achievements |
Studied the evolution of multidrug efflux pumps (RND transporters), and observed the environmental adaption of these pump within specific organisms. The antibiotic and inhibitor specificities of an ancient RND transporter were identified. In this fiscal year FY2018 we could publish (and submit) one review article and one research article.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
The experiments and results were performed very efficiently, by a relatively fast data output and interesting and revealing data, which brought significant new insights in the evolution of multidrug efflux transporters of the RND superfamily. One review article and one research article on this research within one fiscal year was achieved.
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| Strategy for Future Research Activity |
Studying more RND multidrug efflux transporters and also analyze drug resistance in different bacterial strains.
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