2019 Fiscal Year Final Research Report
Development of cancer theranostics system using CO2 generating nanoparticles and ultrasound
| Project/Area Number |
19K21232
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| Project/Area Number (Other) |
18H06114 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0801:Pharmaceutical sciences and related fields
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2018-08-24 – 2020-03-31
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| Keywords | マイクロ流体技術 / in vivoイメージング / がん治療 |
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| Outline of Final Research Achievements |
CO2 generating-Nanoparticles (ABC-NPs) which were composed of phospholipid, cholesterol, and PEG-lipid were prepared by microfluidics techniques using a NanoAssemblr. To generate carbon dioxide (CO2), ammonium bicarbonate (ABC)was used as a buffer. The size of ABC-NPs showed about 60 nm, low PDI, and sphere structure. When ABC-NPs were warmed at 65℃, PDI of ABC-NPs was increased. It assumed that generating CO2 was accompanied by an increase in temperature so that the size of NPs was changed. In addition, ABC-NPs were accumulated in tumor tissue when it was administered to tumor-bearing mice. Therefore, ABC-NPs could work as generating CO2 at tumor tissue and be expected to be an agent cancer theranostics using ultrasound.
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| Free Research Field |
がん治療DDS
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| Academic Significance and Societal Importance of the Research Achievements |
マイクロ流体技術と炭酸水素アンモニウムを用いることでおよそ60 nmの均一なナノ粒子の作製に成功し、温度上昇に伴うCO２の産生とがん組織への集積を示唆した。これまでの報告において100 nm以下のCO2を産生するナノ粒子は存在しないことから、学術的に意義深いものと考えられる。また温度に応答しCO2を産生することから、外部エネルギーを利用したがんの診断・治療システムを可能とするナノ粒子として、がん医療に貢献するものと期待される。
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