Effects of intestinal bacterial fatty acid metabolites on liver disease

2019 Fiscal Year Final Research Report

• Project/Area Number: 19K21261
• Project/Area Number (Other): 18H06147 (2018)
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund (2019); Single-year Grants (2018)
• Review Section: 0803:Pathology, infection/immunology, and related fields
• Research Institution: Osaka City University
• Principal Investigator: Kamiya Tomonori 大阪市立大学, 大学院医学研究科, 助教 (80823682)
• Project Period (FY): 2018-08-24 – 2020-03-31
• Keywords: 腸内細菌 / NASH / リノール酸

Outline of Final Research Achievements

The purpose of this study was to clarify the effects of bacterial linoleic acid (LA) metabolites on obesity-induced liver cancer.
Accumulation of bacterial LA metabolites was observed in the liver, which was increased by a high-LA high fat diet (HFD). A strain with the ability to metabolize LA was successfully isolated from the stool of a high-LA HFD fed mouse and was Lactobacillus. This genus was also increased by the high-LA HFD from 16S rRNA sequencing analysis. Furthermore, suppression of fatty liver was observed with the high-LA HFD, and its relationship with LA metabolites is for further study.

Free Research Field

病態生理学

Academic Significance and Societal Importance of the Research Achievements

食文化の変化による非アルコール性脂肪肝炎から発生する肝がんの治療・予防法の確立は重要な課題である。本研究は、必須脂肪酸であるリノール酸(LA)が肝がん抑制に働くメカニズムを追求しており、臨床現場に還元できる内容となっている。また、LAの供給量が増えることで、乳酸桿菌の増加が認められた。機能性が謳われるLA代謝物が肝臓に蓄積した結果から、LAがプロバイオティクスとして機能していることが明らかとなった。