2019 Fiscal Year Final Research Report
Development of multi-shot irradiation and optimal irradiation technique in patients with brain metastases
| Project/Area Number |
19K21271
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| Project/Area Number (Other) |
18H06161 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0901:Oncology and related fields
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2018-08-24 – 2020-03-31
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| Keywords | 脳転移 / 定位放射線治療 / 多段階連続照射法 |
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| Outline of Final Research Achievements |
Stereotactic radiotherapy (SRT) is a standard therapy in patients with brain metastases, and improvement in the clinical outcome of SRT is important. Traditionally, SRT is delivered by using the same dose distribution on each treatment day. The concept of multi-shot irradiation using combined different dose distributions on each treatment day was developed to improve the dose distribution of SRT. In this study, interfractional tumor volume changes during SRT were analyzed to investigate the optimal number of fractionation.
Based on the evaluation described above, two methods of multi-shot irradiation were developed and evaluated. Both two methods seemed to be useful in point of view of tumor volume change over time. This research could contribute to the development of the optimal irradiation technique and dose fractionation for SRT.
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| Free Research Field |
医歯薬学
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| Academic Significance and Societal Importance of the Research Achievements |
これまでSRTにおける多段階連続照射に関する研究はなく、本研究は新規性・独自性・創造性の高い研究といえる。SRTは転移性脳腫瘍だけでなく、原発性脳腫瘍（良性・悪性含む）や一部の体幹部腫瘍に対しても用いられており、本解析結果を踏まえ上述した他疾患に対する多段階照射の応用が期待される。また近年発展が目覚ましい免疫療法や分子標的療法と本研究成果を組み合わせることにより新たな治療戦略の開発につながる可能性があり、波及効果は大きいと考えられる。
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