2020 Fiscal Year Final Research Report
The translational research for the significance of GPR15 in gastrointestinal cancer
| Project/Area Number |
19K21279
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| Project/Area Number (Other) |
18H06170 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0901:Oncology and related fields
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
Furukawa Kenei 東京慈恵会医科大学, 医学部, 助教 (80624973)
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| Project Period (FY) |
2018-08-24 – 2021-03-31
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| Keywords | 消化器癌 / 抗がん剤抵抗性 / トロンボモジュリン |
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| Outline of Final Research Achievements |
In the present study, we analyzed the expression of GPR15 in various cell lines and the antitumor effect of rTM. the expression level of GPR15 was different among carcinomas, and the appearance of antitumor effect of rTM was different among carcinomas.
The relationship between the direct antitumor effect of rTM and GPR15 is a subject for further study.
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| Free Research Field |
肝胆膵外科
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は難治性の消化器癌に対する新たなバイオマーカーとなりうるGPR15に着目した研究である。消化器癌は化学療法への抵抗性を示した際には分子標的薬や免疫チェックポイント阻害剤による新たな治療法が必要となるが、本研究においては第四の治療標的を見出す研究である。そのため、本研究で得られる成果は癌治療の発展における重要な位置付けとなりうる。
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