2019 Fiscal Year Annual Research Report
固形癌における革新的ゲノム解析法を用いた免疫微小環境ならびに腫瘍不均一性の解明
| Project/Area Number |
19K21289
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| Allocation Type | Multi-year Fund |
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
川口 耕 京都府立医科大学, 医学(系)研究科(研究院), 特任助教 (60825058)
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| Project Period (FY) |
2019-04-01 – 2020-03-31
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| Keywords | 腫瘍免疫 / 免疫微小環境 / 乳癌 / 肝臓癌 |
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| Outline of Annual Research Achievements |
The aim was to examine the immune landscape of breast cancer (BrCa) and hepatocellular carcinoma (HCC) as it relates to aspects of tumor biology, including intra-tumoral genetic heterogeneity and clinical significance. Methods: Using The Cancer Genome Atlas (TCGA) and other large independent datasets, we correlated cytolytic activity (CYT) with mutational, structural, and genetic features of the tumor, as well as clinical outcomes. CYT-high and BrCa HCCs associated with enhanced immunity and better survival. Our findings suggest that proper identification of tumor immune microenvironment could stratify the patients for appropriate treatment based on their biology.
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