2019 Fiscal Year Final Research Report
In vivo analysis of the role of the melanocortin system in erythropoiesis and myelopoiesis
| Project/Area Number |
19K21308
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| Project/Area Number (Other) |
18H06204 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0902:General internal medicine and related fields
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2018-08-24 – 2020-03-31
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| Keywords | 赤血球 / 赤芽球 / 造血 / メラノコルチン / メラノコルチン受容体 / 副腎皮質刺激ホルモン |
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| Outline of Final Research Achievements |
The role of melanocortin, represented by adrenocorticotropic hormone, in erythropoiesis was studied in melanocortin receptor 5 (MC5R)-deficient mice. The number, diameter and morphology of erythrocytes and the weight and histology of hematopoietic organs were analyzed. The results showed no obvious differences between knockout and wild-type mice.
For the purpose of comparing the hematopoietic capacity, a phlebotomy model was created and similar studies were performed. However, there was no significant difference between anemic knockout and wild-type mice.
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| Free Research Field |
発生学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究課題の核となるメラノコルチンによる赤芽球の分化・成熟調節機構は、所属研究室にて発見された(Simamura et al, 2012)。本研究課題は、これを発展させる研究と位置付けられる。本研究により得られる成果は、胎生期における脱核をともなう血球分化、造血機構の解明につながる。さらに、胎児造血に対する母体のエピジェネティックな調節機構の存在およびその破綻に起因する造血障害の発生機序を説明しうるモデルが提案される。加えて、iPS細胞等を用いた安全かつ安定的な人工誘導赤血球を大量生産するための技術開発につながる研究と位置付けられる。
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