2019 Fiscal Year Final Research Report
Study of mechanism involved in unfolded protein response to the formation of fragile plaques in carotid atherosclerosis
Project/Area Number |
19K21354
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Project/Area Number (Other) |
18H06262 (2018)
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund (2019) Single-year Grants (2018) |
Review Section |
0906:Surgery related to the biological and sensory functions and related fields
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Research Institution | Kobe University |
Principal Investigator |
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Project Period (FY) |
2018-08-24 – 2020-03-31
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Keywords | 頚動脈狭窄 / 小胞体ストレス / 脳卒中 |
Outline of Final Research Achievements |
The purpose of this study was to elucidate the mechanisms involved in unfolded protein response to the formation of fragile plaques in carotid atherosclerosis, an important cause of cerebral infarction, and to search for surrogate markers of fragile plaque formation based on the elucidation. The number of positive cells for unfolded protein response associated antibodies in carotid plaques increased in the order of asymptomatic, symptomatic, and progressive stroke group, indicating that persistent unfolded protein response is associated with carotid plaque severity and frangibility. Clinical outcomes showed that the progressive stroke group had predominantly poor outcomes compared to the other groups, and within the group, the outcomes of the patients treated by CAS group was significantly worse than those treated by CEA.
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Free Research Field |
脳神経外科学
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Academic Significance and Societal Importance of the Research Achievements |
本研究の頚動脈プラークにおける小胞体ストレスの関連と臨床成績の結果から、進行性脳卒中群の治療成績向上のためには、現時点ではCEAによるプラーク除去が有効なことを示唆された。これらの所見より、頚動脈で局所的に小胞体ストレスを制御する方法が存在すれば、頚動脈プラークの安定化を図ることが可能となり、外科的治療を含めた総合的な脳卒中予防の治療成績向上が期待される。
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