Elucidation of the mechanism of cell response on three-dimensional surface structure

2019 Fiscal Year Final Research Report

• Project/Area Number: 19K21374
• Project/Area Number (Other): 18H06285 (2018)
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund (2019); Single-year Grants (2018)
• Review Section: 0907:Oral science and related fields
• Research Institution: Fukuoka Dental College
• Principal Investigator: Kaga Naoyuki 福岡歯科大学, 口腔歯学部, 助教 (50824083)
• Project Period (FY): 2018-08-24 – 2020-03-31
• Keywords: マイクロ・ナノパターン / ナノインプリント / 骨芽細胞 / 上皮細胞 / 再生医療 / チタン / PLGA

Outline of Final Research Achievements

In this study, it was investigated the effect of micro/nano pattern for cells. Our nanoimprint method can make possible in producing patternd titanium sheet and PLGA sheet. Osteoblasts and epithelial cells showed different cellular responses on the surface of different micro/nano patterns. In the future, further potential for regenerative medicine is expected by utilizing the effect of this pattern on cell type differences.

Free Research Field

歯科補綴学

Academic Significance and Societal Importance of the Research Achievements

ナノインプリント法を利用することで，異なるマイクロ・ナのパターンを付与した生体材料の作製法を可能とした．これにより安価で用意に生体材料への表面性状を可能とした．
作製されたマイクロ・ナノパターンを付与した生体材料で培養した細胞は，パターンの形状で異なる細胞応答を示した．本研究成果は，種々の目的に適応し多様な分野に応用可能な生体材料の開発に繋がる．