Comprehensive study for clinical application of FGF-2-releasing adhesive resins

2019 Fiscal Year Final Research Report

• Project/Area Number: 19K21380
• Project/Area Number (Other): 18H06292 (2018)
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund (2019); Single-year Grants (2018)
• Review Section: 0907:Oral science and related fields
• Research Institution: Osaka University
• Principal Investigator: Tsuboi Ririko 大阪大学, 歯学研究科, 特任助教(常勤) (20827430)
• Project Period (FY): 2018-08-24 – 2020-03-31
• Keywords: 接着性レジン / FGF-2 / 非生体分解性材料 / ポリマー粒子

Outline of Final Research Achievements

Previously, we reported that the incorporation of FGF-2-loaded polymer particles into the adhesive resin was effective to provide the ability to release FGF-2 and promote tissue regeneration. In this study, aiming at achievement of the adhesive resin acceptable for clinical use, small FGF-2-loaded polymer particles with different kinds of particle size were newly prepared and incorporated into the adhesive resin. Then, the effects of the released FGF-2 on cell proliferation, physical properties and bonding ability of experimental resins were evaluated. The results revealed that the incorporation of FGF-2-loaded particles with an average diameter of 8.7 μm promoted the proliferation of osteoblast-like cells due to the release of FGF-2 from the particles, maintaining clinically acceptable physical properties and dentin bonding ability.

Free Research Field

生体材料学

Academic Significance and Societal Importance of the Research Achievements

再生医療を目的とした薬剤徐放用キャリアの多くが生体分解性材料であるのに対し、本研究で用いたポリマー粒子は、担持した薬剤の放出後でも粒子形態を維持できることから、再建用材料への適用を可能にする世界初の非生体分解性の薬剤徐放用キャリアである。本研究の成果をもとに組織再生誘導能を備えた接着性レジンが実用化できれば、破折歯の接着再建の治療成績を飛躍的に向上させ、口の中で歯をより長く機能させることが可能となる。また、本研究の技術は医科領域にも応用展開が可能であり、極めて発展性が高く社会的意義が高い。